As a pediatric immunologist, you have two patients both around a year old with similar but distinct symptoms. Both patients have hypothyroidism,

As a pediatric immunologist, you have two patients both around a year old with similar but distinct symptoms. Both patients have hypothyroidism, and you have prescribed synthetic thyroid hormone to each. One patient, a girl aged 5 years, has had recurrent thrush infections (yeast infection of the mouth). And the other, a boy aged 18 months, has had several outbreaks of eczema. Family histories show male and female relatives with similar issues or worse for your female patient, and males relatives with similar issues for the male patient. You begin to suspect a heritable autoimmune disorder. (a) Which autoimmune disorders do you think each one has and why (at least 2 reasons for each) (abbreviations for diseases is ok). (b) What gene is defective in each disorder? And how would you test or confirm your diagnoses in part (a)? (c) Your partner suggests that both children should get bone marrow transplants. Do you agree? Why or why not in each case?