base substitution at the beginning of the gene

Generally speaking, which of the following mutations would most severely affect the protein coded for by a gene?

Generally speaking, which of the following mutations would most severely affect the protein coded for by a gene?

  • a base substitution at the beginning of the gene
  • a base substitution at the end of the gene
  • a frameshift deletion at the beginning of the gene
  • a frameshift deletion at the end of the gene

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