Is it reasonable to say that enzymes lower the energy of the transition state for a reaction?

1. Is it reasonable to say that enzymes lower the energy of the transition state for a reaction?

Yes. Like other catalysts, enzymes speed up reactions by lowering the activation energy, which is the energy of the transition state.
No. Since enzymes change pathways of reactions, we cannot say that they lower the energy of the transition state.

2. Why is the reaction faster when the liver is ground up?

Grinding speeds up the reaction of formation of catalase in the liver.
Grinding increases the solubility of catalase.
Grinding increases the surface area.
Grinding allows for more catalase to be extracted from the liver to the solution.

3. Energy profile for conversion of methyl isonitrile (H3CNC) to its isomer acetonitrile (H3CCN). How does the energy needed to overcome the energy barrier compare with the overall change in energy for this reaction?

The magnitude of energy needed to overcome the energy barrier is about the same as the magnitude of the energy change in the reaction.

The magnitude of energy needed to overcome the energy barrier is lower than the magnitude of the energy change in the reaction.

The magnitude of energy needed to overcome the energy barrier is greater than the magnitude of the energy change in the reaction.

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